生物活性：Orphenadrine-d3 (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride[1]. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Orphenadrine-d3 hydrochloride 相关抗体:
PSD95 Antibody
NMDAR1 Antibody
NMDAR2A Antibody
Ionotropic Glutamate Receptor 2 Antibody (YA1143)
GRM5 Antibody (YA1509)
Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)
NR2E1 Antibody (YA2648)
NR2F2 Antibody (YA1223)
KA1 Antibody (YA1879)
GRIK2 Antibody (YA2705)
PSD93 Antibody (YA3187)
分子量：308.86
Formula：C18H21D3ClNO
CAS 号：1309283-23-5
非标记 CAS：341-69-5
中文名称：盐酸奥芬那君-d3； 盐酸邻甲苯海拉明-d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]
[2]. Pubill D, et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132(3):693-702.
 [Content Brief]
[3]. Kornhuber J, et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995102(3):237-46.
 [Content Brief]