生物活性：Diltiazem-(acetoxy-d3) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Diltiazem-(acetoxy-d3) (hydrochloride) 相关抗体:
Annexin VI Antibody
Calbindin Antibody
Calreticulin Antibody
Cardiac Troponin I/TNNC1 Antibody
SCGN Antibody (YA1167)
RAMP1 Antibody (YA1818)
Annexin V Antibody (YA1829)
Striatin 4 Antibody (YA2088)
Fibulin 5 Antibody (YA2448)
RASGRP1 Antibody (YA2546)
Fibulin 1 Antibody (YA2831)
EFEMP1 Antibody (YA2883)
CRCP Antibody (YA3350)
Annexin VII Antibody (YA1138)
Parvalbumin Antibody (YA1249)
Annexin IV Antibody (YA1921)
SERCA2 ATPase Antibody (YA1931)
Stromal Interaction Molecule 1 Antibody (YA2092)
SERCA1 ATPase Antibody (YA2157)
TrpV5 Antibody (YA2284)
NCX1 Antibody (YA2331)
Scramblase 1 Antibody (YA2419)
CAB39 Antibody (YA2761)
CUG BP1 Antibody (YA2806)
C10orf63 Antibody (YA2894)
ITPK1 Antibody (YA3125)
ORAI3 Antibody (YA3128)
ORAI1 Antibody (YA3157)
CREB Regulated Transcription Coactivator 2 Antibody (YA3279)
分子量：454.00
Formula：C22H24D3ClN2O4S
CAS 号：1217860-13-3
非标记 CAS：33286-22-5
中文名称：盐酸地尔硫卓 d3 (盐酸盐)
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.
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[3]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.
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[4]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.
 [Content Brief]
[5]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40.
 [Content Brief]
[6]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.
 [Content Brief]