生物活性：Oltipraz-d3 is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Oltipraz-d3 相关抗体:
PGK1 Antibody
HIF1 alpha Antibody
HIF1 beta Antibody
Keap1 Antibody
Phospho-Nrf2 (Ser40) Antibody (YA169)
CD4 Antibody
Phospho-Nrf2 (Ser40) Antibody (YA168)
PGK1 Antibody (YA862)
HIF 2 alpha Antibody
CA9 Antibody (YA1368)
TARBP2 Antibody (YA1433)
HIF2 alpha Antibody (YA1445)
ORP150 Antibody (YA1478)
SAMHD1 Antibody (YA1542)
PHD3 Antibody (YA1612)
CITED2 Antibody (YA2596)
GCLC Antibody (YA2898)
SV40 T Antigen Antibody (YA3256)
GCLM Antibody (YA1407)
CLEC12A Antibody (YA1419)
ORP1 Antibody (YA1477)
HIF1AN Antibody (YA1907)
OS9 Antibody (YA1939)
PHD2 Antibody (YA2431)
Tat SF1 Antibody (YA2886)
HIF Prolyl Hydroxylases Antibody (YA2975)
HLF Antibody (YA2990)
PHD1 Antibody (YA3325)
分子量：229.36
Formula：C8H3D3N2S3
CAS 号：2012598-51-3
非标记 CAS：64224-21-1
中文名称：吡噻硫酮 d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802.
 [Content Brief]
[3]. Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5.
 [Content Brief]
[4]. Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.
 [Content Brief]
[5]. Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49(2):324-33.
 [Content Brief]