生物活性：Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1][2][3].
Clinical Trial
NCT NumberSponsorConditionStart DatePhaseNCT00753103University Hospital Birmingham NHS Foundation TrustWegener´s Granulomatosis|Renal Limited Vasculitis|Microscopic PolyangiitisJanuary 2003Phase 2NCT01817972Gastroenterology Research of America|UCB PharmaCrohn´s DiseaseMarch 2013Phase 3NCT01446211Nordic Pharma SASWegeners GranulomatosisNovember 2011Phase 3 NCT00052039InterMuneLung Disease|Pulmonary FibrosisApril 2002Phase 3NCT04469842Vanderbilt University Medical Center|Veloxis PharmaceuticalsLung Transplant; ComplicationsAugust 2023Early Phase 1NCT03250143Postgraduate Institute of Medical Education and ResearchChronic Refractory UrticariaDecember 6, 2016Phase 1|Phase 2NCT01381432GlaxoSmithKlineLiver DiseasesDecember 2004NCT01941095Hoffmann-La RocheRheumatoid ArthritisNovember 20, 2013Phase 3NCT01056237Zhi-Hong Liu, M.D.|Nanjing University School of MedicineLupus NephritisFebruary 2010Not ApplicableNCT00461825Poitiers University HospitalKidney TransplantationJuly 1998Phase 3NCT03164473Assistance Publique - Hôpitaux de Paris|French Vasculitis Study GroupEosinophilic Granulomatosis With PolyangiitisMarch 7, 2018Phase 3NCT00400075Hospices Civils de LyonPolyarteritis Nodosa|Microscopic PolyangiitisJuly 1996Phase 4NCT00774852National Institute of Allergy and Infectious Diseases (NIAID)|Immune Tolerance Network (ITN)Lupus Nephritis|Lupus Erythematosus, SystemicNovember 2008Phase 2NCT02598596Ampel BioSolutions, LLC|IND 2 Results LLCGoutDecember 2015Phase 2NCT02929706Sixth Affiliated Hospital, Sun Yat-sen University|Sir Run Run Shaw HospitalThiopurine-induced LeukopeniaJuly 2016Not ApplicableNCT00104299National Institute of Allergy and Infectious Diseases (NIAID)|Immune Tolerance Network (ITN)|Genentech, Inc.Vasculitis|Wegener´s Granulomatosis|Microscopic PolyangiitisJanuary 2005Phase 2|Phase 3NCT00307645Assistance Publique - Hôpitaux de ParisANCA Associated Systemic Vasculitis Including Wegener´s|Granulomatosis and Microscopic Polyangiitis and|Renal Limited VasculitisMay 2003Phase 3NCT00866684Charite University, Berlin, GermanyKidney Transplantation|Skin CancerJanuary 2007Phase 4NCT00615173Sun Yat-sen UniversityKidney Diseases|Lupus Nephritis|Tacrolimus|Induction Phase|Maintenance PhaseJuly 2006Phase 3NCT01172002RenJi Hospital|Changhai Hospital|Shanghai 10th People´s Hospital|Shanghai Zhongshan Hospital|The First Affiliated Hospital with Nanjing Medical University|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|The First Affiliated Hospital of Soochow University|Zhejiang University|Second Affiliated Hospital, School of Medicine, Zhejiang University|First Affiliated Hospital of Wenzhou Medical University|Qilu Hospital of Shandong University|AnHui ShengLi Hospital|First Affiliated Hospital Bengbu Medical College|The First Affiliated Hospital of Anhui Medical UniversityNephritis|LupusMarch 2010Not ApplicableNCT05263505Washington University School of Medicine|Eli Lilly and CompanyMucous Membrane Pemphigoid|Cicatrizing ConjunctivitisFebruary 21, 2022Phase 2NCT02425852Groupe d´Etude Therapeutique des Affections Inflammatoires DigestivesUlcerative ColitisDecember 2016Phase 4NCT03414502University of NebraskaRheumatoid ArthritisAugust 2007Phase 3NCT02247258Universitaire Ziekenhuizen KU Leuven|International organization for the study of inflammatory bowel disease (IOIBD)Crohn Disease|Recurrence|Azathioprine|PreventionOctober 2005Phase 2NCT01235689AbbVie (prior sponsor, Abbott)|AbbVieCrohn´s DiseaseFebruary 11, 2011Phase 3NCT05584228Nantes University Hospital|Groupe d´Etude Therapeutique des Affections Inflammatoires DigestivesCrohn DiseaseApril 1, 2023Not ApplicableNCT02645565Jawaharlal Institute of Postgraduate Medical Education & ResearchLupus NephritisDecember 2015Phase 4NCT04654988Medical University of WarsawMyocarditis|Heart Failure|Endomyocardial Biopsy|Cardiomyopathies, Secondary|ImmunosuppressionMay 1, 2022Phase 4NCT01559142Children´s Memorial Health Institute, PolandCrohn DiseaseNovember 2008Phase 3NCT00525473National Taiwan University HospitalAzathioprine|Thiopurine Methyltransferase|Inosine Triphosphate Pyrophosphatase|Genetic PolymorphismFebruary 2007NCT01823042Jinling Hospital, ChinaCrohn´s DiseaseOctober 2012Not ApplicableNCT04160325Zhu Weiming|Jinling Hospital, ChinaCrohn DiseaseMay 14, 2018Not ApplicableNCT03185611Sixth Affiliated Hospital, Sun Yat-sen University|First Affiliated Hospital, Sun Yat-Sen University|Peking Union Medical College Hospital|Xijing Hospital|Shanghai 10th People´s Hospital|RenJi Hospital|Sir Run Run Shaw HospitalCrohn DiseaseMay 18, 2017Phase 3NCT00626197Genentech, Inc.|Roche Pharma AGLupus Nephritis|Systemic Lupus ErythematosusFebruary 15, 2008Phase 3NCT04660539Hoffmann-La RocheNeuromyelitis Optica Spectrum DisorderMarch 2, 2021Phase 3NCT00204022Frédéric A. Houssiau, MD, PhD|Université Catholique de LouvainLupus NephritisFebruary 2001Phase 3NCT00976690Groupe d´Etude Therapeutique des Affections Inflammatoires DigestivesCrohn DiseaseOctober 2002Phase 3NCT00128895University Medical Center Groningen|ZonMw: The Netherlands Organisation for Health Research and Development|Dutch Arthritis Association|Dutch Kidney FoundationVasculitisJune 2003Phase 4NCT02281799Shaare Zedek Medical Center|Sydney Children´s Hospitals Network|Christchurch HospitalPancreatitis|Inflammatory Bowel DiseasesMarch 2015Phase 4NCT04737343Chinese SLE Treatment And Research Group|Shanghai Zhongshan Hospital|Affiliated Hospital of Jilin University, Changchun,China|Second Affiliated Hospital of Nanchang University|The First Affiliated Hospital of Anhui Medical University|Beijing Shijitan Hospital, Capital Medical University|The Affiliated Hospital of Inner Mongolia Medical University|First Affiliated Hospital of Kunming Medical University|Sichuan Province People´s Hospital|Second Affiliated Hospital, School of Medicine, Zhejiang UniversityANCA Associated Vasculitis|Maintenance TherapyJune 30, 2021Not ApplicableNCT05861297Nahda UniversityImmune Thrombocytopenia PurpuraMay 5, 2020Phase 4NCT00098111Massachusetts General HospitalCrohn´s DiseaseApril 2005Phase 3NCT00537316Merck Sharp & Dohme LLCUlcerative ColitisJuly 2007Phase 3NCT00656656University of LuebeckPemphigusJanuary 2008Phase 2NCT03229746Assiut UniversityImmune ThrombocytopeniaAugust 1, 2017Phase 4NCT05969730Mazandaran University of Medical SciencesAtopic DermatitisAugust 15, 2023Not ApplicableNCT02994927ChemoCentryxANCA-Associated VasculitisMarch 15, 2017Phase 3NCT00230035National Institute of Allergy and Infectious Diseases (NIAID)Systemic Lupus ErythematosusSeptember 2005Phase 2NCT00494741Mario Negri Institute for Pharmacological Research|Agenzia Italiana del FarmacoKidney TransplantMay 2007Phase 4NCT02498977King´s College London|King´s College Hospital NHS Trust|National Institute for Health Research, United KingdomTransplantation, LiverOctober 2015Phase 4NCT00321906University of Chicago|Astellas Pharma Inc|Loyola University|University of Florida|University of Pennsylvania|Baylor College of Medicine|Ochsner Health System|Columbia University|University of Wisconsin, MadisonDelayed Graft Function|Acute Graft RejectionApril 2002Phase 4NCT03791827Xiqiang Dang|The Children´s Hospital Affiliated to Suzhou University|Shandong Provincial Hospital|Guizhou Provincial People´s Hospital|LanZhou University|The First Affiliated Hospital of Inner Mongolia Medical College|People´s Hospital of Zhangjiajie|Puyang Oilfield General Hospital|The First Affiliated Hospital of Anhui Medical University|Guizhou Maternal and Child Health Care Hospital|The Second Affiliated Hospital & Yuying Children´s Hospital of Wenzhou Medical University|Shenzhen Children´s Hospital|The Second Affiliated Hospital of Harbin Medical University|Yichang Central People´s Hospital|Xian Children´s Hospital|Wuhan Children´s Hospital, Tongji Medical College, Huazhong University of Science & Technology|The First People´s Hospital of Yunnan|The First Affiliated Hospital of Xiamen University|The First Affiliated Hospital of Xinxiang Medical College|Shanxi Provincial Maternity and Children´s Hospital|Liaocheng People´s Hospital|Fujian Provincial Hospital|First Affiliated Hospital of Guangxi Medical University|Second Hospital of Lanzhou University|Guangzhou First People´s Hospital|The Second Hospital of Shandong University|Children´s Hospital of Hebei Province|Beijing Children´s Hospital|Zhengzhou Children´s Hospital|The Children´s Hospital of Chongqing Medical University|Wuxi Women´s & Children´s Hospital|The Children´s Hospital of Fudan University|Shanghai Children´s Medical Center|Qilu Children´s Hospital of Shandong University|Second Xiangya Hospital of Central South UniversityLupus Nephritis|Children|Steroid|Immunosuppressive TreatmentDecember 1, 2018NCT02949349Genovate Biotechnology Co., Ltd.,Lupus NephritisJuly 2015Phase 2NCT01727193First Affiliated Hospital, Sun Yat-Sen UniversityMyasthenia GravisSeptember 2012Phase 3NCT04761952Sixth Affiliated Hospital, Sun Yat-sen UniversityInflammatory Bowel Diseases|Crohn Disease|Polyunsaturated Acid LipidosisFebruary 13, 2021Not ApplicableNCT03151525Istituto Clinico Humanitas|Agenzia Italiana del FarmacoColitis, UlcerativeMay 8, 2017Phase 4NCT04882683Shandong Qilu Stem Cells Engineering Co., Ltd.Ulcerative ColitisJune 1, 2021Not ApplicableNCT00425438Hoffmann-La RocheLupus NephritisMarch 2007Phase 3NCT02413047Indiana UniversityInflammatory Bowel Disease|Ulcerative Colitis|Crohn´s DiseaseMay 2015Not ApplicableNCT00695344Fundacion Investigacion y DesarrolloCardiac TransplantJanuary 2006Phase 4NCT02177071Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives|Saint-Louis Hospital, Paris, FranceCrohn´s DiseaseOctober 9, 2015Phase 4NCT01390766GlaxoSmithKlineLiver DiseasesAugust 2002NCT05349006Hospices Civils de LyonCentral Nervous System Inflammation|MOG-IgG Associated DiseaseJanuary 1, 2023Phase 3NCT03370601University Hospital, LilleInflammatory Bowel DiseasesJanuary 3, 2017Not ApplicableNCT01564823Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa|Effice Servicios Para la Investigacion S.L.Crohn´s DiseaseJune 2012Phase 3NCT01880307Erasmus Medical Center|University of Roma La Sapienza|Universitair Ziekenhuis BrusselCrohn´s DiseaseJanuary 2013Phase 4NCT00608894Veloxis PharmaceuticalsAutoimmune HepatitisDecember 2007Phase 2NCT03930264Nova Laboratories Limited|Medicines Evaluation Unit Ltd|Syne Qua Non Limited|Alderley Analytical Ltd|Black County Pathology Services|Diamond Pharma Services Regulatory Affairs Consultancy|Boyd ConsultantsTherapeutic EquivalencyApril 11, 2019Phase 1NCT00748644Assistance Publique - Hôpitaux de ParisWegener Granulomatosis|Microscopic PolyangiitisOctober 2008Phase 3NCT05813860Sixth Affiliated Hospital, Sun Yat-sen UniversityCrohn Disease|InfliximabApril 30, 2023Phase 4NCT03449758Sanofi|Regeneron PharmaceuticalsRheumatoid ArthritisMarch 5, 2018Phase 4NCT02852694PIBD-Net|European CommissionCrohn´s DiseaseFebruary 28, 2017Phase 4NCT03770663Assistance Publique - Hôpitaux de ParisAntisynthetase Syndrome (ASS)|Interstitial Lung DiseaseFebruary 5, 2021Phase 3NCT01284725Assistance Publique Hopitaux De MarseilleNephritis of LupusJanuary 2011Phase 3NCT02517684Erasmus Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development|Hospira, now a wholly owned subsidiary of PfizerCrohn´s DiseaseApril 2015Phase 4NCT03498703Ain Shams University|Capital Birth CenterRecurrent Implantation Failure|In Vitro Fertilization|Intracytoplsmic Sperm InjectionApril 25, 2018Phase 2NCT01697267Cambridge University Hospitals NHS Foundation Trust|Arthritis Research UK|Roche Pharma AG|Genentech, Inc.|University of PennsylvaniaAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis|Microscopic Polyangiitis|Wegener GranulomatosisApril 2013Phase 3NCT00349674Hospices Civils de LyonSystemic Wegener´s GranulomatosisJanuary 1999Phase 3NCT04773392University of Southern California|Veloxis PharmaceuticalsKidney Transplantation|Kidney Transplant RejectionNovember 23, 2021Phase 4NCT03101800Hvidovre University Hospital|Aalborg University Hospital|Zealand University Hospital|University of Copenhagen|Odense University Hospital|Aarhus University Hospital|Viborg Regional Hospital|Vejle Hospital|Sydvestjysk Hospital EsbjergColitis, Ulcerative|Colitis Ulcerative ExacerbationDecember 14, 2016Phase 3NCT00849368University of ZurichInflammatory Bowel DiseaseJanuary 2009Phase 1NCT00626678Tehran University of Medical SciencesPemphigus VulgarisJanuary 2008Phase 2NCT02444728Chinese SLE Treatment And Research Group|Peking Union Medical College HospitalThrombocytopeniaJuly 2015Phase 3NCT02900443Radboud University Medical Center|Leiden University Medical CenterAutoimmune HepatitisJanuary 2017Phase 4NCT03490539Duke University|Beth Israel Deaconess Medical Center|Patient-Centered Outcomes Research InstituteNeurological Disorder|Autoimmune DiseasesMay 7, 2018NCT02579733Kyungpook National University Hospital|CelltrionUlcerative ColitisFebruary 1, 2016Phase 4NCT00504244Erasmus Medical Center|Novartis PharmaceuticalsSystemic Lupus ErythematosusJuly 2007Phase 3NCT00741338Genzyme, a Sanofi Company|BioMarin+Genzyme LLC|SanofiMucopolysaccharidosis ISeptember 2008Phase 1|Phase 2NCT00150891University of Giessen|Heidelberg University|Astellas Pharma Inc|Novartis|Fresenius AG|Hoffmann-La Roche|BiotestRenal Failure, ChronicJanuary 1998NCT05237323I.M. Sechenov First Moscow State Medical UniversityLymphocytic Myocarditis (Disorder)|Heart Failure|Dilated Cardiomyopathy|Cardiomyopathies|Sudden Cardiac DeathOctober 1, 2020Phase 3NCT01663623Human Genome Sciences Inc., a GSK Company|GlaxoSmithKlineVasculitisMarch 20, 2013Phase 3NCT00984568Merck Sharp & Dohme LLCColitis, UlcerativeNovember 2009Phase 3NCT00647166Assistance Publique - Hôpitaux de ParisMPA|PAN or EGPA With FFS=0|At Diagnosis or Within the First 15 Days Following Initiation of CorticosteroidsMay 2008Phase 3NCT00113503National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Prometheus LaboratoriesCrohn´s DiseaseJuly 2005Phase 2NCT01015391Jinling Hospital, ChinaCrohn´s DiseaseNovember 2009Not ApplicableNCT01112215Hospital Universitari Vall d´Hebron Research InstituteSystemic Lupus ErythematosusDecember 2009Phase 4NCT05896605First Affiliated Hospital of Guangxi Medical UniversityNMO Spectrum Disorder|Azathioprine Adverse ReactionJanuary 1, 2020Phase 4NCT02998827Sixth Affiliated Hospital, Sun Yat-sen UniversityCrohn DiseaseNovember 2016Not ApplicableNCT04933292Xiaoli Fan|West China HospitalAutoimmune Hepatitis|Primary Biliary CirrhosisJune 16, 2021Phase 4NCT02332356Tokyo Medical and Dental UniversityCrohn DiseaseSeptember 2014Phase 3NCT00189397All India Institute of Medical Sciences, New DelhiParthenium DermatitisFebruary 2003Not ApplicableNCT03350633Tianjin Medical University General HospitalNeuromyelitis Optica Spectrum Disorders|Neuromyelitis OpticaNovember 1, 2017Phase 2|Phase 3NCT01877746St. Anne´s University Hospital Brno, Czech RepublicInflammatory CardiomyopathyJanuary 2013Phase 3NCT02463331University of Sao Paulo General HospitalAutoimmune HepatitisMay 2003Phase 4NCT02936375RenJi HospitalLupus NephritisSeptember 7, 2017Phase 2NCT00268515National Heart, Lung, and Blood Institute (NHLBI)Lung DiseasesApril 1998Phase 2NCT03393247Sixth Affiliated Hospital, Sun Yat-sen UniversityCrohn DiseaseJune 1, 2017Not ApplicableNCT00521950ZonMw: The Netherlands Organisation for Health Research and Development|Radboud University Medical CenterInflammatory Bowel Diseases|Crohn Disease|Ulcerative ColitisSeptember 2007Not ApplicableNCT00755859A. Manzoni HospitalIGA NephropathyMay 1998Phase 4NCT00431119University Hospital Muenster|Hoffmann-La RocheBullous PemphigoidOctober 1997Phase 2NCT00768729National Institute of Allergy and Infectious Diseases (NIAID)Kidney Failure, Chronic|Kidney Transplantation|ImmunosuppressionMay 2009Phase 1NCT00377637Hoffmann-La Roche|Aspreva PharmaceuticalsLupus NephritisJuly 2005Phase 3NCT05965284Chinese SLE Treatment And Research GroupANCA-associated Vasculitis|Maintenance TherapyMarch 9, 2023Phase 4NCT00399399Hospices Civils de LyonChurg-Strauss SyndromeJuly 1996Phase 4NCT00946946Dr. Falk Pharma GmbHCrohn´s DiseaseFebruary 2002Phase 3NCT01802593Prof. Arie Levine|Wolfson Medical CenterCrohn´s DiseaseFebruary 2013Phase 4NCT01392833A. Manzoni HospitalIgA Nephropathy|Chronic Kidney DiseaseDecember 1999Phase 3NCT03580876Védrines, Philippe, M.D.Clinical Failure After SwitchJuly 23, 2018Phase 4NCT03026907University Medical Center GroningenHand EczemaMay 2016Phase 3NCT00987116Assistance Publique - Hôpitaux de ParisMyasthenia GravisJune 2009Phase 4NCT02939573University of Pennsylvania|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Center for Advancing Translational Sciences (NCATS)|Office of Rare Diseases (ORD)Primary Cutaneous Vasculitis|Cutaneous Polyarteritis Nodosa|IgA Vasculitis|Henoch-Schönlein PurpuraJanuary 1, 2017Phase 2NCT05545384Assistance Publique - Hôpitaux de Paris|Institut National de la Santé Et de la Recherche Médicale, FranceAcute Demyelinating SyndromeJuly 2023Phase 2|Phase 3NCT03681652Schneider Children´s Medical Center, IsraelCrohn DiseaseFebruary 11, 2019NCT03002038Isfahan University of Medical SciencesNeuromyelitis Optica Spectrum DisorderSeptember 2015Phase 2|Phase 3
分子量：281.23
Formula：C513C4H7N7O2S
CAS 号：1346600-71-2
非标记 CAS：446-86-6
中文名称：依木兰-13C4；咪唑硫嘌呤-13C4；硫唑嘌呤-13C4
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Patel, A.A., R.A. Swerlick, and C.O. McCall, Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol, 2006. 55(3): p. 369-89.
 [Content Brief]
[2]. Maltzman, J.S. and G.A. Koretzky, Azathioprine: old drug, new actions. J Clin Invest, 2003. 111(8): p. 1122-4.
 [Content Brief]
[3]. Dubinsky, M.C., Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol, 2004. 2(9): p. 731-43.
 [Content Brief]