生物活性：Thiocolchicine-d3 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Thiocolchicine-d3 相关抗体:
ERK1/2 Antibody
alpha Tubulin Antibody
LC3A/B Antibody
E-Cadherin Antibody (YA470)
Fatty Acid Synthase Antibody (YA766)
DYKDDDDK Tag (FLAG) Antibody
GAPDH Antibody
GFP Antibody
p53 Antibody (YA250)
RUNX2 Antibody
Ferritin Heavy Chain Antibody
COX2 Antibody
Ctip2 Antibody
Cyclin D1 Antibody (YA485)
Cytochrome C Antibody
Beta Tubulin Antibody
c-Myc Antibody
Cyclin E1 Antibody
beta Tubulin Antibody (YA839)
AIF Antibody (YA636)
ALIX Antibody
CNPase Antibody
Cortactin Antibody
COX IV Antibody
COX2/Cyclooxygenase 2 Antibody
Cyclin A2 Antibody
Cyclin B1 Antibody (YA486)
Doublecortin Antibody
DR5 Antibody
Drosha Antibody
分子量：418.52
Formula：C22H22D3NO5S
CAS 号：1314417-95-2
非标记 CAS：2730-71-4
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)