生物活性：Itraconazole-d9 is the deuterium labeled Itraconazole[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[2][3][4][5].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Itraconazole-d9 相关抗体:
Cytochrome C Antibody
SDHA Antibody
Cytochrome P450 17A1 Antibody
Aromatase Antibody
MRP2 Antibody
Shh Antibody
CYP11A1 Antibody
Elongation factor 2 Antibody (YA962)
Elongation factor 2 Antibody (YA964)
PU.1/SPI1 Antibody (YA1116)
Cytochrome P450 1B1 Antibody (YA1836)
Adrenodoxin Antibody (YA2005)
Cytochrome P450 27A1 Antibody (YA2163)
Cytochrome P450 2C9 Antibody (YA2166)
Cytochrome P450 2E1 Antibody (YA2302)
Cytochrome P450 Reductase Antibody (YA2619)
Thromboxane A Synthase Antibody (YA2670)
Ihh Antibody (YA3011)
Cytochrome P450 3A4 Antibody (YA3365)
HSD11B1 Antibody (YA3376)
Cytochrome P450 17A1 Antibody (YA786)
Sulfadimidine Antibody (YA906)
CYP2E1 Antibody
CYP1A2 Antibody
Elongation factor 2 Antibody (YA963)
Anthrax Protective gen Antibody (YA1060)
PLSCR3 Antibody (YA1672)
PROX1 Antibody (YA1754)
Elongation factor 1 gamma Antibody (YA2004)
Cytochrome P450 4A Antibody (YA2087)
分子量：714.69
Formula：C35H29D9Cl2N8O4
CAS 号：1309272-50-1
非标记 CAS：84625-61-6
性状：固体
颜色：White to off-white
中文名称：伊曲康唑-d9；依他康唑-d9
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：-20°C, protect from light, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)