生物活性：Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Glyburide-d3 相关抗体:
Parkin Antibody
MCU Antibody
ATP1A1 Antibody
Calumenin Antibody (YA813)
Mitofusin 2 Antibody
P Glycoprotein Antibody
LIAS Antibody
NDUFS8 Antibody (YA1352)
TOMM20 Antibody (YA1380)
NUDT9 Antibody (YA1453)
MRP1 Antibody (YA1583)
CPS1 Antibody (YA1661)
Complex III Subunit 5 Antibody (YA1865)
NDUFB8 Antibody (YA1947)
MFF Antibody (YA2012)
NDUFS4 Antibody (YA2072)
MT ND1 Antibody (YA2089)
Mitochondrial Fission 1 Protein Antibody (YA2098)
Cyclophilin 40 Antibody (YA2099)
TIMM44 Antibody (YA2207)
NDUFS1 Antibody (YA2535)
CLPX Antibody (YA2814)
LGI1 Antibody (YA2885)
MTCO2 Antibody (YA3254)
Mitochondrial Ferritin Antibody (YA3353)
mtTFA Antibody (YA3360)
Mitofusin 1 Antibody
MRP4 Antibody (YA1166)
Ornithine Carbamoyltransferase/OTC Antibody (YA1230)
NDUFB10 Antibody (YA1330)
分子量：497.02
Formula：C23H25D3ClN3O5S
CAS 号：1219803-02-7
非标记 CAS：10238-21-8
性状：固体
颜色：White to off-white
中文名称：格列本脲 d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month