生物活性：Tianeptine-d12 is a deuterated analog of Tianeptine. Tianeptine is an antidepressant with oral activity and neurochemical properties. Tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in the cortex and white matter, but not against NMDA receptor-mediated excitotoxicity[1][2][3][4].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：449.03
Formula：C21H13D12ClN2O4S
CAS 号：1189870-26-5
非标记 CAS：72797-41-2
中文名称：噻奈普汀 d12
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Wagstaff A J, et al. Tianeptine: a review of its use in depressive disorders[J]. CNS drugs, 2001, 15: 231-259.
[3]. Plaisant F, et al. Neuroprotective properties of tianeptine: interactions with cytokines[J]. Neuropharmacology, 2003, 44(6): 801-809.
 [Content Brief]
[4]. Sharma A K, et al. Effects of calcium channel blocker, nifedipine, on antidepressant activity of fluvoxamine, venlafaxine and tianeptine in mice[J]. Int J Basic Clin Pharmacol, 2015, 4: 1-7.