生物活性：Olmesartan medoxomil-d6 (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM[1][2].
IC50 & Target：AT1 Receptor
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Olmesartan medoxomil-d6 相关抗体:
Natriuretic Peptides A Antibody (YA1381)
Angiotensinogen Antibody (YA2097)
Natriuretic Peptides B Antibody (YA999)
Natriuretic Peptides B Antibody (YA1000)
Natriuretic Peptides B Antibody (YA1001)
AGTR2 Antibody (YA3090)
Angiotensin II Type 1 Receptor Antibody (YA3358)
分子量：564.62
Formula：C29H24D6N6O6
CAS 号：1127298-67-2
非标记 CAS：144689-63-4
中文名称：奥美沙坦酯 d6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9.
 [Content Brief]
[3]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique.
J Young Pharm. 2012 Apr;4(2):88-94.
 [Content Brief]
[4]. Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41(6):848-864.
 [Content Brief]