生物活性：1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models[1][2][3][4][5][6].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量分析的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
1,4-Naphthoquinone-d6 相关抗体:
NF-KB p65 Antibody
Phospho-NF-KB p65 (Ser536) Antibody
TNF alpha Antibody
Phospho-NF-κB p65 (Ser529) Antibody
Ctip2 Antibody
NF-KB p65 Antibody (YA267)
Rb Antibody
Phospho-Rb (Ser807) Antibody
TNF Receptor 2 Antibody
RPA32 Antibody (YA679)
CD40 Antibody
CD40L Antibody
CDT1 Antibody
DNA-PKcs/PRKDC Antibody
DR5 Antibody
Hes1 Antibody
JunB Antibody
LIN28A Antibody
Lin28B Antibody
MCM2 Antibody
Nanog Antibody
NF-KB p105/p50 Antibody
Nucleolin Antibody
PCNA Antibody
PDX1 Antibody
RbBP5 Antibody
RelB Antibody
Ret Antibody
Retinoic Acid Receptor alpha Antibody
S100A4 Antibody
分子量：164.19
Formula：C10D6O2
CAS 号：26473-08-5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (553 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Kumar MR, et al. Cytotoxic, genotoxic and oxidative stress induced by 1,4-naphthoquinone in B16F1 melanoma tumor cells. Toxicol In Vitro. 2009 Mar;23(2):242-50.
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[3]. Kayashima T, et al. 1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis. Cancer Lett. 2009 Jun 8;278(1):34-40.
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[4]. Kobayashi K, et al. Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action. Med Chem. 2011 Jan;7(1):37-44.
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[5]. Samreen, et al. Antibacterial and anti-biofilm efficacy of 1,4-naphthoquinone against Chromobacterium violaceum: an in vitro and in silico investigation. Arch Microbiol. 2024 Dec 7;207(1):11.
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[6]. Coelho Cerqueira E, et al. Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. Bioorg Med Chem. 2011 Dec 15;19(24):7416-24.
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