生物活性：Propoxur-d3 is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3][4].
IC50 & Target：MMP-2
AChE
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Propoxur-d3 相关抗体:
ERK1/2 Antibody
PGK1 Antibody
Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody
Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)
ERK2 Antibody
MMP3 Antibody
Keap1 Antibody
MMP12 Antibody
Phospho-Nrf2 (Ser40) Antibody (YA169)
Catalase Antibody (YA552)
Catalase Antibody (YA811)
ERK5 Antibody
TIMP2 Antibody
ERK1 Antibody
MMP9 Antibody (YA285)
Phospho-Nrf2 (Ser40) Antibody (YA168)
MMP2 Antibody
KGF Antibody
MMP1 Antibody
MMP9 Antibody
Phospho-ERK1/2 (Thr202/Thr185) Antibody
Phospho-ERK1/2 (Tyr204/Tyr187) Antibody
PGK1 Antibody (YA862)
CHRNA9 Antibody
ChAT Antibody
CTGF Antibody
MMP7 Antibody
phospho-ERK1 + 2 (Thr183/Tyr185) Antibody
C Reactive Protein Antibody (YA941)
FAP Antibody (YA1090)
分子量：212.26
Formula：C11H12D3NO3
CAS 号：1219798-56-7
非标记 CAS：114-26-1
中文名称：残杀威-d3；拜力坦-d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (552 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
 [Content Brief]
[2]. Shi Y, et al. Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway. Oncotarget. 2017 Jul 7;8(50):87107-87123.
 [Content Brief]
[3]. Maran E, et al. Effects of aldicarb and propoxur on cytotoxicity and lipid peroxidation in CHO-K1 cells. Food Chem Toxicol. 2010 Jun;48(6):1592-6.
 [Content Brief]
[4]. Mohamadin A M, et al. Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions[J]. Pesticide biochemistry and physiology, 2010, 98(1): 128-134.