生物活性：Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Acetaminophen-13C6 相关抗体:
BNSP Antibody
FACL4 Antibody
BrdU Antibody (YA578)
p300 Antibody
GAPDH Antibody
Glucose 6 Phosphate Dehydrogenase Antibody
COX2 Antibody
Histone H3 (acetyl K27) Antibody
METTL3 Antibody
Acetyl-Histone H3 (Lys27) Antibody
TSG101 Antibody
Alkaline Phosphatase Antibody
ATRX Antibody
Calnexin Antibody (YA573)
COX IV Antibody
COX2/Cyclooxygenase 2 Antibody
Histone H2A(acetyl K9) Antibody
Histone H3 (acetyl K14) Antibody
Histone H3 (acetyl K18) Antibody
Histone H3 (acetyl K56) Antibody
Histone H4 (acetyl K16) Antibody
Histone H4 (acetyl K8) Antibody
Histone H4 (acetyl K5) Antibody
Lamin A/C Antibody
Lamin B1 Antibody
LAMP1 Antibody
LAMP2 Antibody (YA713)
LAMP2a Antibody
NQO1 Antibody (YA697)
NQO1 Antibody (YA261)
分子量：157.12
Formula：C213C6H9NO2
CAS 号：2132405-57-1
非标记 CAS：103-90-2
中文名称：对乙酰氨基酚-13C6；乙酰氨基酚-13C6；扑热息痛-13C6；退热净-13C6；醋氨酚-13C6；对醋氨酚-13C6；索密痛-13C6；乙酰氨基苯酚-13C6；二醋洛尔-13C6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.
 [Content Brief]
[3]. Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.
 [Content Brief]
[4]. Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.
 [Content Brief]
[5]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.
 [Content Brief]