生物活性：Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Amantadine-d6 相关抗体:
ERK1/2 Antibody
Bcl-2 Antibody
E-Cadherin Antibody (YA470)
Fatty Acid Synthase Antibody (YA766)
DYKDDDDK Tag (FLAG) Antibody
GAPDH Antibody
GFP Antibody
p53 Antibody (YA250)
RUNX2 Antibody
Bcl2 Antibody
Ferritin Heavy Chain Antibody
Bax Antibody (YA591)
COX2 Antibody
Ctip2 Antibody
Cyclin D1 Antibody (YA485)
Cyclin E1 Antibody (YA483)
Cytochrome C Antibody
c-Myc Antibody
Cyclin E1 Antibody
AIF Antibody (YA636)
ALIX Antibody
Bad Antibody
Bak Antibody (YA592)
BAX Antibody (YA825)
Bcl-XL Antibody
Bim Antibody
BNIP3 Antibody
CD133 Antibody
Cdk2 Antibody
Cdk4 Antibody
分子量：157.29
Formula：C10H11D6N
CAS 号：1219805-53-4
非标记 CAS：768-94-5
性状：固体
颜色：White to off-white
中文名称：金刚烷胺-d6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years
In solvent：-80°C：6 months，-20°C：1 month
纯度 & 产品资料
纯度： 98.10%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]
[2]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.
 [Content Brief]
[3]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 201278(14):1096-1099.
 [Content Brief]
[4]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan57(1-2):41-52.
 [Content Brief]
[5]. Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 2413(4):539.
 [Content Brief]
[6]. Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct121(4):773-85.
 [Content Brief]
[7]. Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 201536(3):904-910.
 [Content Brief]