生物活性：Isonipecotic acid-d9 is the deuterium labeled Isonipecotic acid[1]. Isonipecotic acid is a GABAA receptor partial agonist[2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Isonipecotic acid-d9 相关抗体:
GABARAP Antibody
IP3 Receptor Antibody (YA1596)
GABA B Receptor 2 Antibody (YA1733)
GABA B Receptor 1 Antibody (YA2418)
GAD65 Antibody (YA758)
GABA A Receptor alpha 1 Antibody (YA1315)
GABA A Receptor beta 2 Antibody (YA1758)
GABA Transporter 1 Antibody (YA1795)
GAD67 Antibody (YA1807)
ABAT Antibody (YA1964)
GABA A Receptor alpha 5 Antibody (YA2249)
GABA A Receptor beta 1 Antibody (YA2261)
BGAT Antibody (YA2741)
GABARAPL2 Antibody (YA2882)
分子量：138.21
Formula：C6H2D9NO2
CAS 号：1219798-43-2
中文名称：4-哌啶甲酸-d9
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5.
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[3]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan44(1):68-75.
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