瑞禧生物货号：Ruixi-B812310
化学名称：N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide
同义名称：N'-(4-Butyl-2-methylphenyl)-N,N-dimethylformimidamide
CAS号：398144-05-3
分子式：C₁₄H₂₂N₂
分子量：218.34
产品类别：Building Blocks; Miscellaneous;
产品应用：N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide is an intermediate in the synthesis of N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine (H831225), which is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYP’s: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).
参考文献：Miyata, N., et al.: Br. J. Pharmacol., 133, 325 (2001); Amaral, S.L., et al.: Am. J. Physiol. Heart Circ. Physiol., 284, H1528 (2003); Mulligan, S.J. and MacVicar, B.A.: Nature, 431, 195 (2004); Poloyac, S.M., et al.: J. Ceteb. Blood Flow Metab., March 29, (2006) in Press
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