瑞禧生物货号：Ruixi-B809473
化学名称：(R)-t-Butyl 2-((4-methyl-1-(1-methylcyclopropyl)-1-oxopentan-2-yl)amino)acetate (>85%)
CAS号：2177287-68-0
分子式：C₁₄H₂₅NO₄
Appearance:White to Pale Yellow Solid
Melting Point:69 - 71°C
分子量：271.35
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
产品类别：Standards; Chiral Molecules;
产品应用：(R)-t-Butyl 2-((4-methyl-1-(1-methylcyclopropyl)-1-oxopentan-2-yl)amino)acetate is an intermediate in synthesizing (R)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt (A605100), an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
参考文献：Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)
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