瑞禧生物货号：Ruixi-B596050
化学名称：BMS 214662
同义名称：(3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile;
CAS号：195987-41-8
分子式：C₂₅H₂₃N₅O₂S₂
Appearance:Light Yellow Solid
Melting Point:>125ºC (dec.)
分子量：489.61
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
产品类别：Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; Benzodiazepines;
产品应用：A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cb.
参考文献：Rose, W.C. et al.: Cancer Res., 61, 7507 (2001); Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2005); Pellicano, F. et al.: Blood, 114, 4186 (2009);
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