瑞禧生物货号：Ruixi-B118660
化学名称：Bardoxolone
同义名称：CDDO; RTA 401; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;
CAS号：218600-44-3
分子式：C₃₁H₄₁NO₄
Appearance:Off-White to Light Brown Solid
Melting Point:>280ºC (dec.)
分子量：491.66
Storage:-20°C
Solubility:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
产品类别：Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
参考文献：Shepler, B., et al.: Clinical. Therap., 34, 1237 (2012); Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012); Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011);
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