瑞禧生物货号：Ruixi-C781800
化学名称：Crenolanib Trifluoroacetic Acid Salt
同义名称：1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine Trifluoroacetic Acid Salt; ARO 002 Trifluoroacetic Acid Salt; CP 868596 Trifluoroacetic Acid Salt; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Trifluoroacetic Acid Salt;
CAS号：1797008-57-1
Alternate CAS #
Free amine: 670220-88-9
分子式：C₂₈H₃₀F₃N₅O₄
Appearance:Off-White to Pale Yellow Solid
Melting Point:214-217°C
分子量：557.56
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Very Slightly)
产品类别：Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRa and PDGFRb. Crenolanib (CP-868569) inhibits the activity of PDGFRa D842V kinase and prevented the phosphorylation of wild type PDGFRa. Crenolanib (CP-868569) possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation.
参考文献：Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);
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