瑞禧生物货号：Ruixi-C381195
化学名称：N1-(5-chloropyridin-2-yl)-N2-((1R,2S,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide
同义名称：N-(5-Chloropyridin-2-yl)-N'-[(1R,2S,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide
CAS号：1255529-25-9
分子式：C₂₄H₃₀ClN₇O₄S
分子量：548.06
产品类别：Standards; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：N1-(5-chloropyridin-2-yl)-N2-((1R,2S,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide is a diastereomer of Edoxaban (E555520), an anticoagulant drug which acts as a direct factor Xa inhibitor. N1-(5-chloropyridin-2-yl)-N2-((1R,2S,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide can be used as a pharmceutical standard for detecting impurities in drugs.
参考文献：Yoshino, T., et al.: U.S. Pat. Appl. Publ. US 20120053349 A1 20120301 (2012); Yoshino, T., et al.: PCT Int. Appl. (2010), WO 2010131663 A1 20101118 (2010); Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)
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