Name:Pioglitazone HCl
Synonyms:AD-4833, U-72107E
CAS Number:112529-15-4
Formula:C19H20N2O3S.HCl
M.w.:392.9
DMSO (mg/mL)Max Solubility:79
DMSO (mM)Max Solubility:201.07
Form:Hydrochloride
SMILES:Cl.CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1
ALogP:4.289
Target:Ferroptosis,P450 (e.g. CYP17),PPAR
Pathway:Metabolism
Information:Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
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