Name:Exarafenib
Synonyms:KIN-002787, KIN-2787, RAF/KIN_2787
CAS Number:2639957-39-2
Formula:C26H34F3N5O3
M.w.:521.58
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:191.73
Form:free base
SMILES:CC(CO)NC1=NC(=CC(=C1)C2=CC(=CC=C2C)NC(=O)N3CCC(C3)CC(F)(F)F)N4CCOCC4
ALogP:4.073
Target:Raf
Pathway:MAPK
Information:Exarafenib(KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.
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