Name:Savolitinib (AZD6094)
Synonyms:HMPL-504, Volitinib
CAS Number:1313725-88-0
Formula:C17H15N9
M.w.:345.36
DMSO (mg/mL)Max Solubility:16
DMSO (mM)Max Solubility:46.33
Form:free base
SMILES:CC([N]1N=NC2=NC=C(N=C12)C3=C[N](C)N=C3)C4=C[N]5C=CN=C5C=C4
ALogP:1.032
Target:c-Met
Pathway:Protein Tyrosine Kinase
Information:Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.
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