Name:Withaferin A
Synonyms:WA, WFA
CAS Number:5119-48-2
Formula:C28H38O6
M.w.:470.6
DMSO (mg/mL)Max Solubility:94
DMSO (mM)Max Solubility:199.75
Form:free base
SMILES:CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(=O)C6(C)C4CCC23C
ALogP:3.388
Target:NF-κB
Pathway:NF-κB
Information:Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.
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