Name:AZD-5153 6-hydroxy-2-naphthoic acid
Synonyms:AZD-5153 HNT salt
CAS Number:1869912-40-2
Formula:C25H33N7O3.C11H8O3
M.w.:667.75
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:149.76
Form:free base
SMILES:COC1=NN=C2C=CC(=N[N]12)N3CCC(CC3)C4=CC=C(OCCN5CCN(C)C(=O)C5C)C=C4.OC(=O)C6=CC=C7C=C(O)C=CC7=C6
ALogP:2.347
Target:Epigenetic Reader Domain,NSD
Pathway:Epigenetics
Information:AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
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