Name:tat-nr2b9c
Synonyms:Nerinetide, NA-1
CAS Number:500992-11-0
Formula:C105H188N42O30
M.w.:2518.88
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:39.7
Form:free base
SMILES:CCC(C)C(NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(N)CC1=CC=C(O)C=C1)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(CC(O)=O)C(=O)NC(C(C)C)C(O)=O
ALogP:-21.34
Target:Others
Pathway:Neuronal Signaling
Information:Tat-NR2B9c (Tat-NR2Bct, NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively, and disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively, also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.
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