Name:Box5
Synonyms:N/A
CAS Number:881188-48-3
Formula:C25H42N6O11S2
M.w.:666.76
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:149.98
Form:free base
SMILES:CSCCC(N)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CS)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(O)=O
ALogP:-5.2
Target:Wnt/beta-catenin
Pathway:Stem Cells & Wnt
Information:Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
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