Name:JNJ-10198409
Synonyms:N/A
CAS Number:627518-40-5
Formula:C18H16FN3O2
M.w.:325.34
DMSO (mg/mL)Max Solubility:65
DMSO (mM)Max Solubility:199.79
Form:free base
SMILES:COC1=CC2=C(C=C1OC)C3=C(C2)C(=N[NH]3)NC4=CC=CC(=C4)F
ALogP:4.49
Target:PDGFR
Pathway:Protein Tyrosine Kinase
Information:JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.
瑞禧生物是您专业的小分子合成定制合作伙伴。我们专注于为医药研发、材料科学及学术研究提供从毫克到公斤级的一站式合成解决方案。无论是常规分子、复杂手性化合物、同位素标记物还是特定杂质，我们的资深团队都能凭借先进技术平台高效完成。我们始终坚持严格的质量控制，确保产品纯度与结构准确，并恪守保密承诺。选择瑞禧生物，就是选择可靠与精准，让我们以卓越的合成能力，加速您的创新突破。欢迎垂询，定制您的专属分子。