Name:BI-671800
Synonyms:AP-761, Cmpd A
CAS Number:1093108-50-9
Formula:C25H26F3N5O3
M.w.:501.5
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:199.4
Form:Free Base
SMILES:CN(C)C1=NC(=NC(=C1CC(O)=O)N(C)C)CC2=CC=C(NC(=O)C3=CC=C(C=C3)C(F)(F)F)C=C2
ALogP:4.5
Target:Prostaglandin Receptor
Pathway:GPCR & G Protein
Information:BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.
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