Name:Alsterpaullone
Synonyms:Alp, 9-Nitropaullone, NSC 705701
CAS Number:237430-03-4
Formula:C16H11N3O3
M.w.:293.28
DMSO (mg/mL)Max Solubility:25
DMSO (mM)Max Solubility:85.24
Form:Free Base
SMILES:[O-][N+](=O)C1=CC2=C([NH]C3=C2CC(=O)NC4=CC=CC=C34)C=C1
ALogP:2.817
Target:Apoptosis related,Caspase,CDK,GSK-3
Pathway:Cell Cycle
Information:Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
瑞禧生物是您专业的小分子合成定制合作伙伴。我们专注于为医药研发、材料科学及学术研究提供从毫克到公斤级的一站式合成解决方案。无论是常规分子、复杂手性化合物、同位素标记物还是特定杂质，我们的资深团队都能凭借先进技术平台高效完成。我们始终坚持严格的质量控制，确保产品纯度与结构准确，并恪守保密承诺。选择瑞禧生物，就是选择可靠与精准，让我们以卓越的合成能力，加速您的创新突破。欢迎垂询，定制您的专属分子。