Name:VX-803 (M4344)
Synonyms:ATR inhibitor 2
CAS Number:1613191-99-3
Formula:C25H29F2N9O3
M.w.:541.55
DMSO (mg/mL)Max Solubility:15
DMSO (mM)Max Solubility:27.7
Form:free base
SMILES:NC1=N[N]2C=C(F)C=NC2=C1C(=O)NC3=C(N4CCC(CC4)C(=O)N5CCN(CC5)C6COC6)C(=CN=C3)F
ALogP:-0.338
Target:ATM/ATR,Chk
Pathway:PI3K/Akt/mTOR
Information:VX-803 (M4344, ATR inhibitor 2) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.
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