Name:N-Ethylmaleimide (NEM)
Synonyms:N/A
CAS Number:128-53-0
Formula:C6H7NO2
M.w.:125.13
DMSO (mg/mL)Max Solubility:25
DMSO (mM)Max Solubility:199.79
Form:free base
SMILES:CCN1C(=O)C=CC1=O
ALogP:0.16
Target:Cysteine Protease,DUB
Pathway:Proteases
Information:N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.
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