Name:Triptolide (PG490)
Synonyms:NSC 163062
CAS Number:38748-32-2
Formula:C20H24O6
M.w.:360.4
DMSO (mg/mL)Max Solubility:72
DMSO (mM)Max Solubility:199.78
Form:free base
SMILES:CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2O
ALogP:0.872
Target:ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-κB
Pathway:NF-κB
Information:Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.
瑞禧生物是您专业的小分子合成定制合作伙伴。我们专注于为医药研发、材料科学及学术研究提供从毫克到公斤级的一站式合成解决方案。无论是常规分子、复杂手性化合物、同位素标记物还是特定杂质，我们的资深团队都能凭借先进技术平台高效完成。我们始终坚持严格的质量控制，确保产品纯度与结构准确，并恪守保密承诺。选择瑞禧生物，就是选择可靠与精准，让我们以卓越的合成能力，加速您的创新突破。欢迎垂询，定制您的专属分子。