Name:Mitoxantrone (NSC-301739) 2HCl
Synonyms:NSC-301739 2HCl
CAS Number:70476-82-3
Formula:C22H29ClN4O6.2HCl
M.w.:517.4
DMSO (mg/mL)Max Solubility:89
DMSO (mM)Max Solubility:172.01
Form:Dihydrochloride
SMILES:Cl.Cl.OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C3=C(O)C=CC(=C3C2=O)O
ALogP:0.832
Target:Apoptosis related,COVID-19,PKC,Topoisomerase
Pathway:DNA Damage/DNA Repair
Information:Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.
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