Name:Floxuridine (NSC 27640)
Synonyms:Deoxyfluorouridine, FUDR,NSC 27640
CAS Number:50-91-9
Formula:C9H11FN2O5
M.w.:246.19
DMSO (mg/mL)Max Solubility:49
DMSO (mM)Max Solubility:199.03
Form:free base
SMILES:OCC1OC(CC1O)N2C=C(F)C(=O)NC2=O
ALogP:-1.775
Target:Apoptosis related,CMV,DNA/RNA Synthesis
Pathway:DNA Damage/DNA Repair
Information:Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
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