生物活性：MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
MPP+-d3 iodide 相关抗体:
Parkin Antibody
MCU Antibody
Mitofusin 2 Antibody
LIAS Antibody
NDUFS8 Antibody (YA1352)
TOMM20 Antibody (YA1380)
NUDT9 Antibody (YA1453)
CPS1 Antibody (YA1661)
Complex III Subunit 5 Antibody (YA1865)
NDUFB8 Antibody (YA1947)
MFF Antibody (YA2012)
NDUFS4 Antibody (YA2072)
MT ND1 Antibody (YA2089)
Mitochondrial Fission 1 Protein Antibody (YA2098)
Cyclophilin 40 Antibody (YA2099)
TIMM44 Antibody (YA2207)
NDUFS1 Antibody (YA2535)
CLPX Antibody (YA2814)
MTCO2 Antibody (YA3254)
Mitochondrial Ferritin Antibody (YA3353)
mtTFA Antibody (YA3360)
Mitofusin 1 Antibody
Ornithine Carbamoyltransferase/OTC Antibody (YA1230)
NDUFB10 Antibody (YA1330)
NDUFB11 Antibody (YA1331)
NDUFB2 Antibody (YA1335)
NDUFB4 Antibody (YA1338)
NDUFB9 Antibody (YA1340)
NDUFC2 Antibody (YA1343)
NDUFS3 Antibody (YA1346)
分子量：300.15
Formula：C12H9D3IN
CAS 号：207556-07-8
非标记 CAS：36913-39-0
性状：固体
颜色：Off-white to light yellow
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)