生物活性：Imatinib-d3 (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.
细胞效力(Cellular Effect)
BaF3
Cell Line
Type
Value
Description
References
BaF3
IC50
436 nM
Compound: 3
Inhibition of human BCR-ABL1 autophosphorylation expressed in mouse BA/F3 cells by ELISA
Inhibition of human BCR-ABL1 autophosphorylation expressed in mouse BA/F3 cells by ELISA
[PMID: 23611771]
BaF3
IC50
682 nM
Compound: 3
Inhibition of human BCR-ABL1 expressed in mouse BA/F3 cells assessed as cell growth inhibition by ATP-depletion assay
Inhibition of human BCR-ABL1 expressed in mouse BA/F3 cells assessed as cell growth inhibition by ATP-depletion assay
[PMID: 23611771]
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Imatinib-d3 hydrochloride 相关抗体:
c-Kit Antibody (YA502)
Phospho-PDGFR beta (Y740) Antibody
PDGFR alpha Antibody
PDGF B Antibody (YA1556)
PDGFR beta Antibody (YA1925)
Bcr Antibody (YA2746)
Phospho-PDGFR beta (Tyr740) Antibody (YA3062)
ABL2 Antibody (YA3203)
c-Kit Antibody
SCF Antibody
BLNK Antibody (YA2282)
BMF Antibody (YA2436)
CrkL Antibody (YA2577)
ABI2 Antibody (YA2840)
分子量：496.62
Formula：C29H28D3N7O
CAS 号：1134803-18-1
非标记 CAS：152459-95-5
性状：固体
颜色：Light yellow to yellow
中文名称：伊马替尼 d3 (盐酸盐)
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month