生物活性：Ketoconazole-d8 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Ketoconazole-d8 相关抗体:
Cytochrome C Antibody
Rab5 Antibody
RAB8A Antibody
Epac1 Antibody
GRB2 Antibody
RAB7 Antibody
Ras Antibody
RASA1 Antibody
RhoA Antibody (YA093)
SDHA Antibody
Cytochrome P450 17A1 Antibody
Aromatase Antibody
RhoA Antibody
RhoA/B/C Antibody
CYP11A1 Antibody
Rab10 Antibody (YA1789)
Rab7B Antibody (YA1798)
Rab9 Antibody (YA1800)
GTPase NRAS Antibody (YA1830)
GTPase HRAS Antibody (YA1833)
Cytochrome P450 1B1 Antibody (YA1836)
Adrenodoxin Antibody (YA2005)
Cytochrome P450 27A1 Antibody (YA2163)
Cytochrome P450 2C9 Antibody (YA2166)
Rab4 Antibody (YA2272)
Cytochrome P450 2E1 Antibody (YA2302)
IQGAP1 Antibody (YA2388)
G3BP Antibody (YA2432)
Cytochrome P450 Reductase Antibody (YA2619)
Thromboxane A Synthase Antibody (YA2670)
分子量：539.48
Formula：C26H20D8Cl2N4O4
CAS 号：1217706-96-1
非标记 CAS：65277-42-1
性状：固体
颜色：Off-white to yellow
中文名称：酮康唑 d8
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years
In solvent：-80°C：6 months，-20°C：1 month
纯度 & 产品资料
纯度： 99.79%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75.
 [Content Brief]
[3]. Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70.
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[4]. Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151(9):4301-12.
 [Content Brief]
[5]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.
 [Content Brief]