生物活性：Bendroflumethiazide-d5 (Bendrofluazide-d5) is the deuterium labeled Bendroflumethiazide (HY-B1363).Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
药代动力学(Parmacokinetics)[2]
Species
Dose
Route
Indicator
value
Human
10000 ug
p.o.
Tmax
2 hr
Human
10000 ug
p.o.
Cmax
86 ng/mL
Human
10000 ug
p.o.
T1/2
3 hr
Human
10000 ug
p.o.
Vd
1.48 L/kg
分子量：426.45
Formula：C15H9D5F3N3O4S2
CAS 号：1330183-13-5
非标记 CAS：73-48-3
性状：固体
颜色：White to off-white
中文名称：苄氟噻嗪-d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)