生物活性：Atorvastatin-d5 (sodium) is the deuterium labeled Atorvastatin sodium. Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Atorvastatin-d5 sodium 相关抗体:
HMGCS2 Antibody
HMGB1 Antibody
HMGCR Antibody
Baf180 Antibody (YA1176)
BANF1 Antibody (YA1740)
LEF1 Antibody (YA3164)
HMGA1 Antibody (YA1185)
HMGA2 Antibody (YA1186)
Baf57 Antibody (YA2110)
HMGN2 Antibody (YA2839)
HMG4 Antibody (YA2992)
HMGB2 Antibody (YA2995)
HMGCL Antibody (YA3024)
分子量：585.65
Formula：C33H29D5FN2NaO5
CAS 号：222412-87-5
非标记 CAS：134523-01-6
中文名称：阿托伐他汀 d5 (钠盐)
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.
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[3]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
 [Content Brief]