生物活性：1'-Hydroxymidazolam-d4 is the deuterium labeled 1'-Hydroxymidazolam. 1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
1'-Hydroxymidazolam-d4 相关抗体:
FMO3 Antibody (YA1992)
分子量：345.79
Formula：C18H9D4ClFN3O
CAS 号：1781843-10-4
非标记 CAS：59468-90-5
性状：液体
颜色：Colorless to light yellow
中文名称：咪达唑仑杂质1-d4
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Solution, -20°C, 2 years
纯度 & 产品资料
纯度： 99.12%
参考文献
[1]. Hasegawa T, et, al. Increase in the systemic exposure of primary metabolites of Midazolam in rat arising from CYP inhibition or hepatic dysfunction. Drug Metab Pharmacokinet. 2017 Feb; 32(1): 69-76.
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[2]. Balk M, et, al. Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Sci Rep. 2017 Jun 14; 7(1): 3503.
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[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
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