生物活性：Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Crizotinib-d5 相关抗体:
Met (C-Met) Antibody
Phospho-c-Met (Tyr1349) Antibody
Mst2 Antibody
Phospho-Met Antibody (YA175)
Caveolin 1 Antibody (YA1782)
SESN2 Antibody (YA1934)
ALKBH2 Antibody (YA2047)
ALKBH4 Antibody (YA2050)
ALK-1 Antibody (YA2457)
ALKBH1 Antibody
Phospho-GAB1 (Tyr627) Antibody
Caveolin 2 Antibody (YA2387)
SESN1 Antibody (YA2739)
Caveolin 3 Antibody (YA2869)
分子量：455.37
Formula：C21H17D5Cl2FN5O
CAS 号：1395950-84-1
非标记 CAS：877399-52-5
性状：固体
颜色：White to yellow
中文名称：克唑替尼 d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month