瑞禧生物货号：Ruixi-B399700
化学名称：BIRH 414
同义名称：11-Ethyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; BIRH 414 BS; USP Nevirapine Related Compound A; Nevirapine EP Impurity A; Nevirapine USP Related Compound A
Impurity:Nevirapine EP Impurity A; Nevirapine USP Related Compound A
CAS号：133627-17-5
分子式：C₁₄H₁₄N₄O
分子量：254.29
产品类别：Standards; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：BIRH 414 (Nevirapine EP Impurity A; Nevirapine USP Related Compound A) is an derivative of 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine, a highly potent inhibitor of wild-type human immunodeficiency virus type 1. BIRH 414 was also shown to exhibit binding affinity towards HIV-1 reverse transcriptase enzyme. This is also an impurity found in Nevirapine (N391275).
参考文献：Tavlarakis, A., et al.: Molec. Stimu., 35, 1224 (2009); Singh, J., et al.: Oxidation. Commun., 32, 13 (2009); Rizzo, R.C., et al.: J. Med. Chem., 45, 2970 (2002);
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