瑞禧生物货号：Ruixi-B208380
化学名称：[3aR,4R(1E,3S),5R,6aS]-5-Benzoyloxy-4-(3-hydroxy-4-phenoxy-1-buten-1-yl)-hexahydro-2H-cyclopenta[b]furan-2-one
同义名称：(3aR,4R,5R,6aS)-5-(Benzoyloxy)-4-[(1E,3S)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2-one
CAS号：208111-89-1
分子式：C₂₄H₂₃ClO₆
分子量：442.89
产品类别：Standards; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：[3aR,4R(1E,3S),5R,6aS]-5-Benzoyloxy-4-(3-hydroxy-4-phenoxy-1-buten-1-yl)-hexahydro-2H-cyclopenta[b]furan-2-one can be used as reagent/reactant in preparation of 15-Fluoro prostaglandin FP agonists as a new class of topical ocular hypotensives for the treatment of glaucoma. It can be obtained from (-)-Corey Lactone Benzoate (C694990) which a corey lactone derivative used in the preparation prostaglandin analogues for use as vasolidator as well as EP4 receptor agonists.
参考文献：Andersen, N.H. et al.: Prostaglandins, 22, 809 (1981); Klimko, P., et al.: Bioorgan. Med. Chem., 12, 3451-3469 (2004); Ohta, C. et al.: J. Org. Chem., 74, 8298 (2009); Skuballa, W. et al.: Angew. Chem., 93, 1080 (1981);
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