瑞禧生物货号：Ruixi-A793925
化学名称：Atrasentan
同义名称：Altrasentan; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic Acid; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid; (+)-A 127722; A 147627; ABT 627;
CAS号：173937-91-2
Alternate CAS #
HCl Salt: 195733-43-8
分子式：C₂₉H₃₈N₂O₆
Appearance:Off-White Solid
Melting Point:121-126ºC
分子量：510.62
Storage:-20°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly)
产品类别：Standards; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
参考文献：Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);
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