瑞禧生物货号：Ruixi-A790040
化学名称：Ataciguat
同义名称：5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide; HMR 1766;
CAS号：254877-67-3
分子式：C₂₁H₁₉Cl₂N₃O₆S₃
分子量：576.49
产品类别：Standards; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.
参考文献：Butt, E., et al.: J. Biol. Chem., 269, 14509 (1994),
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