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CAS:1236699-92-5|AS-703026

作者:瑞禧生物 发布时间:2024-08-08 09:09:44 次浏览

瑞禧生物货号:Ruixi-A780100
化学名称:AS-703026
同义名称:N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;
CAS号:1236699-92-5
分子式:C₁₅H₁₅FIN₃O₃
分子量:431.2
产品类别:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用:AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Potent MEK inhibitor.
参考文献:Billadeau, D., et al.: Cancer Res., 55, 3640 (1995), Kolch, W., et al.: Biochem. J., 351, 289 (2000), Smith, M., et al.: Leukemia, 17, 274 (2003), Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2008),
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