瑞禧生物货号：Ruixi-A628850
化学名称：Aminopterin
同义名称：N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid;
Impurity:Methotrexate EP Impurity B
CAS号：54-62-6
分子式：C₁₉H₂₀N₈O₅
Appearance:Yellow to Dark Yellow Solid
Melting Point:>200°C (dec.)
分子量：440.41
Storage:-20°C
Solubility:DMF (Slightly), DMSO (Slightly, Heated)
产品类别：Standards; Amino Acids; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
参考文献：Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),
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