瑞禧生物货号：Ruixi-A601630
化学名称：N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester
CAS号：1013330-79-4
分子式：C₂₂H₂₁N₃O₃
Appearance:White Solid
Melting Point:172-174°C
分子量：375.42
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
产品类别：Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester is a biaryl benzamides that exhibit inhibitory selectivity over class II Histone Deacetylase (HDACs) and as well as class I HDACs. N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester was deteremined to be a potent and selective inhibitor of HDAC with reduced off-target activity and tumor growth inhibition activity.
参考文献：Witter, D.J., et al.: Bioorg. Medn. Chem. Letters., 18, 726 (2008);
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