瑞禧生物货号：Ruixi-A596515
化学名称：(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride
同义名称：Methyl (1R,4S)-4-Aminocyclopent-2-ene-1-carboxylate Hydrochloride
CAS号：426226-35-9
Alternate CAS #
352226-74-5
分子式：C₇H₁₁NO₂ • HCl
分子量：141.17 + 36.46
产品类别：Building Blocks; Miscellaneous;
产品应用：(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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